Description
Roitt’s Essential Immunology 13th Edition by Peter J. Delves, ISBN-13: 978-1118415771
[PDF eBook eTextbook] – Available Instantly
- Publisher : Wiley-Blackwell
- Publication date : January 13, 2017
- Edition : 13th
- Language : English
- 576 pages
- ISBN-10 : 1118415779
- ISBN-13 : 978-1118415771
NOTE: This book is a standalone book and will not include any access codes.
The textbook of choice for students and instructors of immunology worldwide.
Roitt’s Essential Immunology clearly explains the key principles needed by medical and health sciences students, from the basis of immunity to clinical applications. A brand new introduction sets the scene to section 1, Fundamentals of Immunology, introducing the microbial world and the strategies the body employs to defend itself. Each chapter then guides the reader through a different part of the immune system, and explains the role of each cell or molecule individually, and then as a whole. Section 2, Applied Immunology, discusses what happens when things go wrong, and the role the immune system plays alongside the damaging effects of a disease, including cancer, immunodeficiency, allergies and transplantation and the beneficial effects of vaccines.
The 13th edition continues to be a user-friendly and engaging introduction to the workings of the immune system, whilst supporting those who require a slightly more detailed understanding of the key developments in immunology. The content has been fully updated throughout and includes:
- An expansion on key clinical topics, including: innate immunity, autoimmune conditions, asthma, primary immunodeficiency, and HIV/AIDS
- Beautifully presented with improved artwork and new illustrations
- A range of learning features, including introduction re-cap boxes, end of chapter and section summaries to aid revision, as well as further reading suggestions, and a glossary to explain the most important immunology terms.
Table of Contents:
Cover
Title Page
About the authors
Acknowledgments
Preface
Abbreviations
How to use your textbook
About the companion website
Part 1: Fundamentals of immunology
CHAPTER 1: Innate immunity
Introduction
Knowing when to make an immune response
Pattern recognition receptors detect nonself
Immune responses are tailored towards particular types of infection
Innate versus adaptive immunity
External barriers against infection
Cells of the immune system
The beginnings of an immune response
There are several classes of pattern recognition receptors
Phagocytic cells engulf and kill microorganisms
Phagocytes employ an array of killing mechanisms
Complement facilitates phagocytosis and bacterial lysis
Humoral mechanisms provide an additional defensive strategy
Natural killer cells kill virally infected cells
Dealing with large parasites
The innate immune system instigates adaptive immunity
SUMMARY
FURTHER READING
CHAPTER 2: Specific acquired immunity
Just to recap …
Introduction
Antigens – “shapes” recognized by the immune system
Antibody – a specific antigen recognition molecule
Clonal selection
Immunological memory
Antigen specificity
Vaccination produces acquired memory
Cell‐mediated immunity protects against intracellular organisms
Integration of the immune response
Immunopathology
SUMMARY
FURTHER READING
CHAPTER 3: Antibodies
Just to recap …
Introduction
The division of labor
Five classes of immunoglobulin
The IgG molecule
The structure and function of the immunoglobulin classes
Genetics of antibody diversity and function
SUMMARY
FURTHER READING
CHAPTER 4: Membrane receptors for antigen
Just to recap …
Introduction
The B‐cell surface receptor for antigen (BCR)
The T‐cell surface receptor for antigen (TCR)
The generation of diversity for antigen recognition
Invariant natural killer T‐cell receptors bridge innate and adaptive immunity
NK receptors
The major histocompatibility complex (MHC)
Pathogen recognition receptors provide the first line of detection for microbial antigen
SUMMARY
FURTHER READING
CHAPTER 5: Antigen‐specific recognition
Just to recap …
Introduction
What antibodies see
Identifying B‐cell epitopes on a protein
Thermodynamics of antibody–antigen interactions
Specificity and cross‐reactivity of antibodies
What the T‐cell sees
Processing of intracellular antigen for presentation by class I MHC
Processing of extracellular antigen for class II MHC presentation follows a different pathway
Cross‐presentation of antigens
The nature of the “groovy” peptide
The αβ T‐cell receptor binds to a combination of MHC and peptide
T‐cell recognition of non‐protein antigens
Antigen recognition by γδ T‐cells
Superantigens are extremely powerful activators of T‐cells
Why do αβ T‐cells need to recognize antigen in such a complex way?
SUMMARY
FURTHER READING
Chapter 6: The anatomy of the immune response
Just to recap …
Introduction
The location of the immune system
The skin immune system
Mucosal immunity
The blood and lymphatic systems
Organized lymphoid tissue
Lymphocyte homing
Lymph nodes
Spleen
Bone marrow is a major site of antibody synthesis
The liver contains a variety of immune system cells
Immunologically privileged sites
The handling of antigen
SUMMARY
FURTHER READING
Chapter 7: Lymphocyte activation
Just to recap …
Introduction
Clustering of membrane receptors frequently leads to their activation
T‐lymphocytes and antigen‐presenting cells interact through several pairs of accessory molecules
The activation of T‐cells requires two signals
Triggering the T‐cell receptor complex
Protein tyrosine phosphorylation is an early event in T‐cell signaling
Downstream events following TCR signaling
CD28 co‐stimulation amplifies TCR signals and blocks apoptosis
Activated T‐cells exhibit distinct gene expression signatures
Epigenetic control of T‐cell activation
Activated T‐cells undergo an essential metabolic shift
Metabolic control of T‐cell differentiation
Damping T‐cell enthusiasm
Dynamic interactions at the immunological synapse
B‐cells respond to three different types of antigen
The nature of B‐cell activation
Dynamic interactions at the BCR synapse
SUMMARY
FURTHER READING
Chapter 8: The production of effectors
Just to recap …
Introduction
Effector mechanisms of innate and adaptive immunity
Cytokines influence the generation and function of effectors within the adaptive immune system
Cytokines act as intercellular messengers
Chemokines also play important roles in orchestrating immune responses
Cytokines and chemokines act through distinct classes of cell surface receptors
Cytokine receptor signal transduction cascades
Cytokine activities are fine‐tuned through a variety of mechanisms
Activated T‐cells proliferate in response to cytokines
Different T‐cell subsets can make different cytokine patterns
Cells of the innate immune system shape the Th1/Th2/Th17/Tfh response
Policing the adaptive immune system
CD8 T‐cell effectors in cell‐mediated immunity
Proliferation and maturation of B‐cell responses are mediated by cytokines
What is going on in the germinal center?
The synthesis of antibody
Immunoglobulin class switching occurs in individual B‐cells
Factors affecting antibody affinity in the immune response
Memory cells
SUMMARY
FURTHER READING
Chapter 9: The regulation of the immune response
Just to recap …
Introduction
Immunogenetics
Antigenic competition
Complement and antibody help regulate immune responses
Activation‐induced cell death
CD28 superfamily members that negatively regulate the immune response
Immunoregulation by T‐cells
Regulatory immunoneuroendocrine networks
Dietary effects on immunity
The influence of gender and aging
SUMMARY
FURTHER READING
Chapter 10: Development and evolution of the immune response
Just to recap …
Introduction
ONTOGENY
CD antigens
Hematopoietic stem cells
The thymus is required for T‐cell development
T‐cell ontogeny
T‐cell tolerance
B‐cells differentiate in the fetal liver and then in bone marrow
B‐1 and B‐2 cells represent two distinct populations
Development of B‐cell specificity
B‐cell tolerance
Lymphocytes go through antigen‐independent and antigen‐dependent stages of differentiation
Natural killer (NK) cell ontogeny
Neonatal immunity
PHYLOGENY
The evolution of the immune response
The evolution of distinct B‐ and T‐cell lineages was accompanied by the development of separate sites for differentiation
Cellular recognition molecules exploit the immunoglobulin gene superfamily
SUMMARY
FURTHER READING
Part 2: Applied immunology
CHAPTER 11: Adversarial strategies during infection
Just to recap …
Introduction
Infection remains a major healthcare problem
Inflammation revisited
Bacterial survival strategies
The host counterattack against bacteria
The habitat of intracellular bacteria allows avoidance of many of the host defenses
Virus survival strategies
The host counterattack against viruses
Immunity to fungi
Immunity to parasitic infections
Prions
SUMMARY
FURTHER READING
CHAPTER 12: Vaccines
Just to recap …
Introduction
Passively acquired immunity
Principles of vaccination
Killed organisms as vaccines
Live attenuated organisms have many advantages as vaccines
Subunit vaccines
Newer approaches to vaccine development
Current vaccines
Vaccines under development
Vaccines against parasitic diseases have proved particularly difficult to develop: malaria
Vaccines for protection against bioterrorism
Immunization against cancer
Other applications for vaccines
Adjuvants
SUMMARY
FURTHER READING
CHAPTER 13: Immunodeficiency
Just to recap …
Introduction
Deficiencies of pattern recognition receptor signaling
Phagocytic cell defects (Table 13.1)
Primary immunodeficiency affecting other cells of the innate response
Complement system deficiencies (Table 13.2)
Cytokine and cytokine receptor deficiencies
Primary B‐cell deficiency (Table 13.3)
Primary T‐cell deficiency (Table 13.4)
Severe combined immunodeficiency (SCID)
Diagnosis of primary immunodeficiencies
Treatment of primary immunodeficiencies
Secondary immunodeficiency
Acquired immunodeficiency syndrome (AIDS)
SUMMARY
FURTHER READING
CHAPTER 14: Allergy and other hypersensitivities
Just to recap …
Introduction
Type I hypersensitivity – IgE‐mediated mast cell degranulation
Type II hypersensitivity – antibody‐dependent cytotoxicity
Type III hypersensitivity – immune complex‐mediated
Type IV hypersensitivity – cell‐mediated (delayed‐type)
An addition to the original classification – stimulatory hypersensitivity (“type V”)
Innate hypersensitivity reactions
SUMMARY
FURTHER READING
Chapter 15: Transplantation
Just to recap …
Introduction
Types of graft
Types of rejection
Genetic control of transplantation antigens
Some other consequences of MHC incompatibility
Mechanisms of graft rejection
Matching the donor and recipient
Immunosuppression
Is xenografting a practical proposition?
Stem cell therapy
Clinical experience in grafting
The fetus as an allograft
SUMMARY
FURTHER READING
CHAPTER 16: Tumor immunology
Just to recap …
Introduction
Cellular transformation and cancer
Cell‐intrinsic mechanisms of tumor suppression
Cell‐extrinsic mechanisms of tumor suppression
The cancer problem from an immune perspective
Inflammation can enhance tumor initiation, promotion, and progression
Tumor antigens
Classes of tumor antigens
Approaches to cancer immunotherapy
Passive immunotherapy with monoclonal antibodies
Unmasking of latent T‐cell responses
Antigen‐independent cytokine therapy
Vaccination approaches
Ex vivo expanded lymphocytes or dendritic cells
SUMMARY
FURTHER READING
CHAPTER 17: Autoimmune diseases
Just to recap …
Introduction
The spectrum of autoimmune disease
What causes autoimmune disease?
Mechanisms in autoimmune disease
Pathogenic effects of autoantibody
Pathogenic effects of complexes with autoantigens
T‐cell‐mediated hypersensitivity as a pathogenic factor in autoimmune disease
Some other diseases with autoimmune activity
Measurement of autoantibodies
Therapeutic options
SUMMARY
FURTHER READING
Glossary
Index
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